Author

Douglas F. Covey

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Open access Sep 2026

The orientation of cholesterol’s hydroxy group affects its membrane dynamics and intracellular transport

Summary The brain, though less than 10% of body mass, contains about 25% of total cholesterol (CHL), emphasizing CHL’s key role in neuronal function. Many actions of CHL are stereospecific, as shown by differences from its 3α-hydroxy epimer, epicholesterol (epiCHL). How this minor structural change alters membrane prop...

Line Lauritsen, Amanda Pauli, Miklas P. W. Larsen et al. · iScience · 0 citations

#protein folding Open access Aug 2026

Regulation of the human voltage-gated proton channel by membrane sterols

This work identified the key molecular determinant in the hHv1 channel that mediates cholesterol inhibition and also provided a mechanism linking the conversion between demosterol and cholesterol by DHCR24 to pH homeostasis in many cells, such as phagocytes, cardiomyocytes, neurons and microglial cells.

Shuo Han, R. Duan, Sarah Applewhite et al. · bioRxiv · 0 citations