Author

Douglas A. Mitchell

3 papers indexed here

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Open access Sep 2026

Substrate-Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis.

Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side chains in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). ApyO is a cytochrome P450 that forms a C─C bond between two tyrosines in a YLY motif in the substrate ApyA, the precursor pept...

Chandrashekhar Padhi, Dinh T. Nguyen, Ling-Yang Zhu et al. · Angewandte Chemie · 0 citations

Open access Sep 2026

Antibodies targeting a conserved cryptic epitope at the influenza hemagglutinin head-stem interface via distinct binding modes

Influenza A virus continues to pose pandemic threats, as demonstrated by the recent global spread of highly pathogenic H5N1 strains. Consequently, the development and characterization of vaccines targeting zoonotic influenza subtypes have become a major focus of the field. In this study, we characterize two broadly rea...

Guthrie L. Stroh, Hui-Bin Lv, Chun-Ke Chen et al. · bioRxiv · 0 citations

Open access Aug 2026

Enzymatic formation of a conserved isoaspartate in ribosomal protein uS11

Isoaspartate (isoAsp) formation is typically viewed as a “molecular clock” through nonenzymatic degradation of aspartate or asparagine during protein aging. Here we report a nearly universal enzymatic pathway for the formation of a conserved isoAsp in the bacterial ribosomal protein uS11. Proteome-wide protein-protein...

Yanqing Xue, Chandrima Majumdar, Salimat O. Sofela et al. · bioRxiv · 0 citations