Author

Dong-Sheng Zhou

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Open access Sep 2026

Dynamic orchestration of structural and immune cells in acute Pseudomonas aeruginosa pneumonia revealed by time-resolved single-cell and spatial transcriptomics

Background Pseudomonas aeruginosa pneumonia triggers a complex, dynamic host response, yet the cellular coordination of inflammation and repair remains poorly defined. Methods We performed time-resolved single-cell RNA sequencing (scRNA-seq) on murine lungs across five timepoints (0–96 h post-infection) and integrated...

Fu-Liang Zong, Yan Wang, Ling-Fei Hu et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

A Dual role of alveolar macrophage in driving host defense and pulmonary immunopathology during hypervirulent Acinetobacter baumannii pneumonia.

It is suggested that targeting AM phenotypic plasticity represented a promising therapeutic strategy to alleviate excessive immunopathology while preserving protective host defense while preserving protective host defense during hvAB pneumonia.

Duo Su, Yan Wang, Lu Li et al. · Protein & Cell · 0 citations