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Author

Dong-Seok Lee

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3 papers indexed here

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Open access Oct 2026

PRDX1 as a Redox Gatekeeper at Mitochondrial-ER Contact Sites: Implications for Kidney Fibrosis Progression and Therapy

Peroxiredoxins (PRDXs) constitute a class of thiol-dependent oxidoreductive regulatory factors whose functions extend beyond peroxide detoxification to include the regulation of oxidoreductive signaling, organelle homeostasis, and cell fate determination. The emerging role of PRDX1–6 in fibrotic diseases—particularly P...

Yang Zhang, Jaeyeon Lee, Nan-Nan Yu et al. · 0 citations
Open access Aug 2026

Dual-mode SOX2 regulation by miR-150 via mRNA suppression and autophagy controls stem cell fate

A role for miR-150 deficiency in biasing ectoderm–mesoderm lineage specification in hPSCs is defined and SOX2 is identified as a key downstream node regulated primarily through altered mRNA stability, with additional involvement of an autophagy-associated pathway.

Xing Zhen, Hyebin Koh, Dong-Seok Lee et al. · 0 citations
#protein folding Open access Sep 2026

Targeting Lung Cancer Stem Cells with Trimebutine: Synergistic Antitumor Activity in Combination with Cisplatin

Overall, trimebutine targets lung CSC populations by disrupting GPCR–ion channel–Hippo signaling crosstalk, providing a strong preclinical rationale for trimebutine–cisplatin combination strategies to overcome drug resistance and recurrence in lung cancer.

Jihye Seo, Heejin Lee, Dong Kyu Choi et al. · 0 citations

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