Jul 2026
11β-HSD1 may Aggravate Sepsis-associated Endothelial Dysfunction by Activating the NF-κB/MAPK Pathway and NLRP3 Inflammasome.
11β-HSD1 may exacerbate sepsis-associated endothelial dysfunction by promoting NF-κB/MAPK signaling and NLRP3 inflammasome activation and targeting this axis represents a potential therapeutic approach for sepsis-related endothelial injury, though further validation is warranted.
Dan Wu, Dong-Mei Zhu, Haidong Qin et al.
· Current Medicinal Chemistry · 0 citations