The gut–lung axis represents a predominantly gut-to-lung communication network through which gut microbiota and their metabolites influence pulmonary immunity. In asthma, gut dysbiosis—characterized by reduced microbial diversity, depletion of short-chain fatty acid (SCFA)-producing taxa, and expansion of pro-inflammat...
Feng-Xian Ni, Chun-Feng Pan, Hui-Hui Chen et al.· Frontiers in Immunology· 0 citations
Ovarian cancer remains the most lethal gynecologic malignancy, a status largely attributable to late-stage diagnosis and inevitable chemoresistance. The cGAS-STING pathway, a cornerstone of innate immune surveillance, has emerged as a critical nexus linking genomic instability to antitumor immunity—a connection of pa...
Hui-Hui Chen, Feng-Xian Ni, Dong-Hui Huang et al.· Frontiers in Immunology· 0 citations
It is argued that the cuproptosis-immune axis warrants systematic exploration as a potential target for disease-modifying therapy, while acknowledging the substantial hurdles that must be overcome before clinical translation can be contemplated.
Feng-Xian Ni, Jie Hu, Pei-sheng Chen et al.· International Immunopharmaco...· 0 citations
This review presents an integrated framework in which redox signals dynamically reshape the epigenetic and epitranscriptomic landscape, thereby locking immune cells into pathogenic states and aims to shift COPD management from symptom control toward durable, mechanism-driven disease modification.
Chun-Feng Pan, Qiong Wan, Feng-Xian Ni et al.· Frontiers in Immunology· 0 citations
The bidirectional metabolism-m6A crosstalk as a theoretical framework requiring experimental validation, and single-cell m6A sequencing, spatial metabolomics, and CRISPR screening as tools to accelerate precision TCM for COPD are outlined.
Hui-Hui Chen, Feng-Xian Ni, Dong-Hui Huang et al.· Frontiers in Immunology· 0 citations
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