Author

Dong-Dong Liu

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Sep 2026

Discovery of FM-604, a Benzyl-Substituted Pyrimidinedione PPO Inhibitor with Potent Postemergence Herbicidal Activity

Protoporphyrinogen IX oxidase (PPO) is a validated target for fast-acting herbicides. To identify low-dose PPO-inhibiting leads, 41 benzyl-substituted pyrimidinedione derivatives were designed by side-chain optimization of epyrifenacil and synthesized. In greenhouse postemergence screening, FM-604 provided 100% contr...

Jia-Lin Ye, Hong-Yan Pei, Dong-Dong Liu et al. · Journal of Agricultural and... · 0 citations

Aug 2026

Discovery of FM-2665 as a Potent Arylpyrazole Insecticidal and Acaricidal Candidate: Rational Design via Pyridine Bioisosterism and Terminal Alkyl Optimization.

FM-2665 (A14) showed the highest overall activity and represents a promising lead for further optimization and safety evaluation, and molecular docking and DFT calculations suggested that additional predicted contacts involving Gln96 and Val126, together with a narrower HOMO-LUMO gap, may contribute to the observed str...

Xiaowen Du, Dong-Dong Liu, Qingjie Bi et al. · Journal of Agricultural and... · 0 citations

Jul 2026

Novel Cyclopropyl-Uracil Derivatives as Potent Herbicides: Design, Synthesis, Activity, and Structure-Activity Relationship.

Herbicides are critical for agricultural weed management. Thirty-seven cycloalkyl-substituted pyrimidinedione derivatives were designed and synthesized via molecular hybridization to explore efficient herbicidal leads. All compounds displayed outstanding postemergence activity against broadleaf weeds, and several exhib...

Hong-Yan Pei, Jia-Lin Ye, Dong-Dong Liu et al. · Journal of Agricultural and... · 0 citations