Author

Dong-Dong Cao

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Review Open access Oct 2026

Cartilage Extracellular Matrix Homeostasis in Knee Osteoarthritis: Pathomechanisms and Therapeutic Targeting

Knee osteoarthritis (KOA) is a degenerative joint disease primarily driven by the disruption of homeostasis in the chondrocyte extracellular matrix (CECM). This review systematically examines the central role of CECM homeostasis in KOA pathogenesis and summarizes recent advances in this field. We synthesized contempora...

Chao Du, Ji-Wei Zhong, Jia-Lin Yang et al. · Journal of Cellular and Mole... · 0 citations

Open access Oct 2026

Biofilm-host immunometabolic crosstalk in Staphylococcus aureus orthopedic implant infection: mechanisms and translational constraints

Orthopedic implant biofilms are not only antibiotic-tolerant bacterial communities but metabolically active niches that reshape host immunity. Compared with planktonic infection, mature biofilms impose spatial and metabolic constraints that can uncouple leukocyte recruitment from sterilizing activity. Neutrophils can p...

Ji-Xin Chen, Qin-Xin Zhou, Dong-Dong Cao et al. · Frontiers in Immunology · 0 citations