Open access
Jul 2026
N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases
Dynamic allostery is established as the mechanism of N-terminal activation in this subclass of serine proteases in a pathogenic methicillin-resistant S. aureus strain and mutational perturbation of this dynamic network modulates substrate engagement and catalytic activity in a manner consistent with dynamic control of binding competence.
Eunjeong Lee, J. Redzic, Samrat Sarkar et al.
· Science Advances · 0 citations