Various 3,5-disubstituted isothiazolo[4,3-b]pyridines were previously shown to be potent inhibitors of the lipid kinase PIKfyve, displaying broad-spectrum antiviral activity. To further study their structure-activity relationship and to discover novel skeletons as antivirally active PIKfyve inhibitors, a scaffold hoppi...
Ling-Jie Gao, M. Froeyen, Chieh-Wen Lo et al.· Bioorganic chemistry (Print)· 0 citations
Background/Objectives: SARS-CoV-2, the causative agent of COVID-19, relies on its main protease (Mpro) for viral replication, making this enzyme an attractive target for antiviral drug development. In the present study, we investigated whether a library of previously synthesized thiazole/benzothiazole-based thiazolidin...
A. Petrou, Aliki Papadimitriou-Tsantarliotou, Hathaichanok Chuntakaruk et al.· The biochemist· 0 citations
Kaposi's sarcoma-associated herpesvirus (KSHV) establishes latent infection in humans, but under conditions of immune suppression, it may reactivate and contribute to severe diseases, including Kaposi's sarcoma (KS) and B-cell malignancies. The KSHV genome encodes a single G protein-coupled receptor (GPCR), open readin...
Qianqian Kong, Brent Van Bosstraeten, S. de Jonghe et al.· Biochemical Pharmacology· 0 citations
Today's in silico design pipelines can directly yield functional proteinaceous binders without the need for additional experimental screening using phage display or related technologies, and demonstrate that modern in silico design pipelines can directly yield functional proteinaceous binders without the need for addit...
Thibault Vantieghem, Julie Delepine, Sam Noppen et al.· Protein Science· 0 citations
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