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Aug 2026

Design of Quinazoline Dual Inhibitors Targeting Focal Adhesion Kinase and Polo-like Kinase 1 for Metastatic Cancers: QSAR, Pharmacophore Modelling, and Molecular Docking Approaches.

INTRODUCTION FAK and PLK1 are regulators of oncogenic signaling and metastasis, and their coinhibition offers a synergistic anticancer strategy. This study employed computational modeling to design quinazoline-based scaffolds as potential dual FAK-PLK1 inhibitors. METHODS 54 quinazoline derivatives were analyzed usin...

M. Garhewal, Dipti Pal, A. K. Gupta et al. · 0 citations

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