Faecalibacterium prausnitzii attenuates diabetes-associated affective disorders by suppressing neuroinflammation through the SCFAs/FFAR3/NF-κB/NLRP3 pathway.
BACKGROUND Diabetes-associated affective disorders are a global health burden tightly linked to the gut microbiota. The depletion of Faecalibacterium prausnitzii (F. prausnitzii) is a shared feature of diabetes and depression, yet its therapeutic potential and mechanisms remain unclear. METHODS We first analyzed the...