Author

Dia A. Ghose

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Open access Aug 2026

Seed-Guided De Novo Design Expands the Structural Diversity of Antitoxin Protein Binders

These results establish motif scaffolding of surface-complementing seeds as an effective strategy for overcoming current limitations of de novo generative models, enabling the design of proteins that can engage challenging interface sites.

D. Britton, Dia A. Ghose, J. Halpin et al. · bioRxiv · 0 citations