Background: Gastric cancer (GC) is one of the most common malignant tumors in the digestive tract, characterized by a high degree of malignancy and a poor prognosis. Complex disease heterogeneity, late diagnosis, and suboptimal treatment often lead to poor prognoses for patients. In addition to genetic alterations and...
Di-Di Yuan, Yan-Ling Li, H. Yi et al.· Cureus· 0 citations
This review systematically examines the intricate regulatory network of cellular senescence, encompassing multiple pathways including telomere dysfunction, DNA damage response, epigenetic remodeling, hormone signaling, and metabolic reprogramming, and integrating such strategies with conventional therapies holds promis...