Construction of Axial Chirality via Amino-Acid-Catalyzed Asymmetric Reductive Desymmetrization of 2-Aryl-isophthalaldehydes
Chiral biaryls with active ortho-substitutions are important building blocks for industrial and academic applications like ligands, catalysts, pharmaceuticals, and materials. Presently, there is high demand for the stereoselective synthesis of both (r)- and (s)-enantiomers of configurationally stable, axially chiral...