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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Deyu Fang

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Review Open access Aug 2026

Precision Drug Delivery Strategies for Treatment-Resistant Depression: Opportunities and Challenges of FUS-BBBO and Spatial Molecular Profiling

The review proposes a three-step translational framework—patient stratification, target constraint, and cargo matching—and delineates five interlinked clinical development barriers: long-term safety of repeated BBB opening, technical standardization and reproducibility, quantifiable intracerebral PK, biological hit verification, and mechanism-enriched trial design.

Chungang Zhang, Deyu Fang, Lin Zhang · 0 citations

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