Enhancing enzyme performance without protein engineering remains a central challenge in biocatalysis. Here, we report the unusual discovery that nanoparticles densely functionalized with DNA, commonly known as spherical nucleic acids (SNAs), can bind enzymes without chemical conjugation, affinity tags, or engineered re...
Biological systems often regulate catalysis by organizing enzymes within dense, multivalent, and nanostructured environments. Nanomaterials can recreate selected features of these environments, but their effects on enzymes range from inhibition to activity enhancement depending on the chemistry of their surface ligands...
Gabriel Gilman, Atri Bhattacharya, Niloufar Yavari et al.· ACS Applied Materials and In...· 0 citations
Proteins and nucleic acids represent nature’s most versatile biomolecules. By leveraging the functionality of proteins and the programmability of nucleic acids, along with the exquisite recognition properties of both, protein-nucleic acid conjugates can unlock hybrid systems that outperform either component alone. In...
Sasha B. Ebrahimi, Devleena Samanta· Bioconjugate chemistry· 0 citations
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