Formulation and Evaluation Monoporous Hollow Microspheres of Itraconazole- for Pulmonary Drug Delivery
Background: Itraconazole is a broad-spectrum triazole antifungal drug, but its poor aqueous solubility, variable oral bioavailability and first-pass metabolism limit predictable therapeutic exposure. Pulmonary delivery can provide high local antifungal concentration in lung tissues while reducing systemic exposure. Obj...