Author

Derui Zhao

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Open access Aug 2026

V600E biases the BRAF kinase domain toward an activation-compatible conformational ensemble through long-range dynamic rewiring

A model in which V600E preorganizes the inactive-like BRAF kinase domain toward activation-compatible conformations through conformational reweighting and long-range dynamic rewiring may facilitate oncogenic signaling in the presence of the additional regulatory interactions required for complete kinase activation.

Bao Zhang, Qi Xi, Yu-Meng Ying et al. · RSC Advances · 0 citations

Open access Jul 2026

Network reorganization of a cold-adapted β-glucosidase couples conformational flexibility to catalytic efficiency under low-temperature conditions

It is suggested that cold adaptation in pBGL may involve not only enhanced flexibility but also network-mediated organization of conformational dynamics, providing a structural framework for understanding the activity–stability balance of cold-active enzymes.

Xian He, Meng-Ting Liu, Xintong Li et al. · Frontiers in Microbiology · 1 citation

Open access Jul 2026

Temperature-Dependent Reorganization of Conformational Dynamics and Interaction Networks Underlies Thermostability in PET-Degrading Enzymes

Polyethylene terephthalate (PET) is one of the most widely used synthetic plastics and a major contributor to global plastic pollution because of its high resistance to degradation. Enzymatic degradation by PET hydrolases (PETase) has emerged as a sustainable strategy for PET recycling; however, the limited thermostabi...

Hui Duan, Chen Wan, Bu-Qing Wang et al. · International Journal of Mol... · 0 citations