Exploring the Design Space of 310-helical Bundles using Non-canonical Amino Acid
Discussion and ConclusionThe (ELUULK) 4 3 10 -helical bundle displays strongly position-dependent mutational tolerance.Surface residues can be readily substituted while preserving the 3 10 architecture, whereas the interfacial Aib positions and hydrophobic core impose much tighter geometric constraints.Computational an...