Open access
Jul 2026
CRISPR-engineered deletion of POGZ alters transcription factor binding at promoters of genes involved in synaptic signaling
An allelic series of CRISPR-engineered human induced pluripotent stem cell (hiPSC) clones harboring mono- and bi-allelic POGZ deletions are created and shared molecular consequences suggest key points of convergence that connect gene regulation to neuronal function in the etiology of neurodevelopmental pathologies.
M. Moyses-Oliveira, Yating Liu, Serkan Erdin et al.
· HGG advances · 1 citation