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Author

D. David

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2 papers indexed here

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Open access Oct 2026

Effects of prucalopride on anxiety and depressive symptoms among constipated patients: A meta-analysis of randomized controlled trials.

AIMS Prucalopride, a 5-HT4 receptor agonist, has shown potential for rapid anxiolytic and antidepressant effects in preclinical studies. This meta-analysis aims to evaluate changes in anxiety and depressive symptoms after prucalopride treatment in chronically constipated adults. METHODS A systematic search of PubMed,...

Lucie Lebon, Denis J. David, M. Gasnier et al. · 0 citations
Open access Aug 2026

Prucalopride repurposing: 5-HT4 receptor agonists in anxiety and depression.

Major depressive disorder remains a leading cause of disability worldwide, and current antidepressant treatments are limited by a delayed onset of action, modest remission rates, and residual symptoms. Emerging evidence suggests that selective targeting of specific serotonergic receptors may offer faster and more preci...

Salma R. Abdennebi, Karen Rodriguez-Lua, Hugo Bottemanne et al. · 0 citations

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