Denis E. Demin

SLE-Associated rs2295613(A) Allele Strengthens a Predicted c-MYC Motif and Enhances SLAMF1 Promoter Reporter Activity in B Cells

Highlights What are the main findings? rs2295613(A) increased SLAMF1 promoter reporter activity in Raji, MP1, and primary CD19+ B cells. Motif disruption and partial MYC depletion reduced the activity of the rs2295613(A)-containing reporter. What are the implications of the main findings? The regulatory activity associ...