Deng-Yan Bai

Lactate-driven lactylation reprograms chondrocyte fate and joint inflammation in osteoarthritis: linking metabolism with epigenetic regulation

The sustained progression of osteoarthritis (OA) arises not only from mechanical injury and inflammatory stimulation but also from the gradual loss of chondrocyte homeostatic identity. However, a unifying mechanism explaining how metabolic abnormalities within the joint microenvironment are converted into relatively st...