Author

Deepak Singh

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Review Open access 2026

Histone Deacetylases and Their Inhibitors: Classification, Clinical Development, and FDA-Approved Therapeutic Indications

Histone deacetylases (HDACs) are vital regulators of gene expression and chromatin structure. Their abnormal overactivity has been closely linked to the progression of various solid tumors, making them a significant focus of cancer research. HDAC inhibitors (HDACis) have shown clinical promise, particularly in the trea...

Amrita Singh, Deepak Singh · Biological sciences · 0 citations

Sep 2026

Structure-based discovery of coumarin-derived HDAC2 inhibitor through integrated computational bioassays, steered molecular dynamics, network analysis and SAR

A structure–activity relationship (SAR)-guided strategy was employed to identify novel coumarin-based HDAC2 inhibitors, highlighting the coumarin scaffold, an additional aromatic ring, a 3–6 atom linker, a furan bridge, and terminal hydroxyl or methoxy groups as key structural features.

Amrita Singh, Deepak Singh · Main group chemistry (Print) · 0 citations