The adult hematopoietic system is established during embryogenesis through the generation of hematopoietic stem and progenitor cells (HSPCs) within specialized transient niches, yet the signaling mechanisms that coordinate this process remain poorly understood. Here, we identify a developmental role for kainate recepto...
M. Parada-Kusz, S. Wattrus, Jacquelyn Jacobs et al.· bioRxiv· 0 citations
Klebsiella pneumoniae is a common cause of sepsis in adults and children. Given the emergence of multidrug-resistant isolates, there is an urgent need to develop novel therapeutic strategies. Essential bacterial genes and their products, which are critical to survival and replication, represent intrinsic vulnerab...
C. Wijers, J. Bagnall, Deborah T. Hung· Journal of the Pediatric Inf...· 0 citations
It is shown that myeloid-derived suppressor cells (MDSCs) act as a key immunologic pivot point in severe COVID-19, and this multimodal and high-dimensional dataset with curated clinical metadata provides a foundational and clinically relevant resource for modeling host immune response biology in health and disease.
Kamil Slowikowski, Pritha Sen, C. Cosgriff et al.· Journal of Immunology· 0 citations
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