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Author

Debarun Patra

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Review Open access Oct 2026

Clinical trials in a dish: cardiometabolic drug development with biological and digital twins

Preclinical drug development has long relied on animal models to predict safety and efficacy before agents enter human trials, despite critical differences between human and animal model physiology. The withdrawal of rosiglitazone, rofecoxib, and terfenadine due to cardiovascular toxicity exemplifies the translational...

Debarun Patra, Ibrahim M. Sayed, R. Venkateshappa et al. · 0 citations
Open access Aug 2026

Generation of two induced pluripotent stem cell lines from Fabry disease patients carrying GLA mutations

Fabry disease is a rare genetic disease caused by loss-of-function in the GLA gene. This gene encodes the lysosomal enzyme α-galactosidase A (α-Gal A). A deficiency of α-Gal A results in the globotriaosylceramide buildup throughout the major organs, which is associated with increased mortality from cardiac disease in p...

Debarun Patra, D. Cabrera, Xiaochun Yang et al. · 0 citations

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