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Author

Deanna M. Langfitt

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Open access Jul 2026

Co-delivery of lentiviral vectors and Cas9-containing virus-like particles enables rapid, scalable manufacture of gene-edited CAR T cells

Chimeric antigen receptor T cell immunotherapies are transforming therapies for hematological malignancies and solid tumors and can be enhanced by targeted gene knockout. Here, we report lentiviral-based virus-like particles that package and deliver Cas9 ribonucleoproteins to primary human T cells. Using distinct pseud...

Francesca Ferrara, Matthew M Wielgosz, Jeoungeun J. Park et al. · 0 citations

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