Author

Dexiong Chen

2 papers indexed here

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Open access Oct 2026

Joint protein, mRNA and DNA sequence design and optimization with nucleotide-level Potts models

NuCaliby is introduced, a structure-conditioned model that jointly designs amino acid, mRNA, and DNA sequences of a protein at nucleotide resolution that extends protein design beyond the amino acid level, enabling joint optimization across the central dogma of molecular biology.

Błażej Banaszewski, Lars J. Dornfeld, De-Xiong Chen et al. · bioRxiv · 0 citations

Open access Jul 2026

Machine learning-guided discovery of a conserved plasmid proteomic signature enables MALDI-TOF MS detection of pOXA-48-carrying Enterobacterales

This approach reframes the resistance prediction task from inferring a resistance phenotype to detecting a conserved plasmid through its expressed proteomic signature and has the potential to enable rapid MALDI-TOF MS-based diagnostics for a wide range of plasmid-based resistance determinants.

Janko Sattler, J. Mueller-Reif, Dexiong Chen et al. · bioRxiv · 0 citations