Author

De-Wen Tong

3 papers indexed here

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Aug 2026

Targeting viral Fe-S clusters with TEMPOL confers broad-spectrum anti-coronavirus activity.

Coronaviruses (CoVs) can cause severe respiratory and enteric diseases, posing major threats to human health and the livestock industry. However, the host metabolic mechanisms underlying viral replication remain unclear. Using porcine epidemic diarrhea virus (PEDV) as the primary model, this study investigated the role...

Le-Yu Hu, Letao Gao, Xing-Wei Fu et al. · Veterinary Microbiology · 0 citations

Open access Sep 2026

Hijacking of host PCNA by circovirus replication-associated protein to recruit POLD1 drives viral DNA replication and is inhibited by R428

Circoviruses are the smallest known mammalian viruses with a single-stranded circular genome, whose replication capacity is highly dependent on host factors. Although the virus-encoded replication-associated protein (Rep/Rep’) plays a critical role in circovirus DNA replication, it lacks polymerase activity. Here, we u...

Lei-Xin Zhu, Guan Zhang, Ying-Ying Pu et al. · PLoS Pathogens · 0 citations

Open access Sep 2026

PEDV envelope protein promotes viral replication by remodeling host iron homeostasis via the TRIM28-KLF15-FPN axis

ABSTRACT Porcine epidemic diarrhea virus (PEDV), a member of the Alphacoronavirus genus, causes severe enteric disease with up to 100% mortality in suckling piglets. Iron is an essential micronutrient for the replication of various pathogens, including viruses, which hijack host iron resources to support their prolifer...

Le-Yu Hu, Ru Tian, Letao Gao et al. · Journal of Virology · 0 citations