Cancer immunotherapy is frequently hindered by the immunosuppressive tumor microenvironment. Although metal ions have been viewed as essential nutrients or cytotoxic payloads, emerging evidence reveals that they are potent immune modulators that orchestrate the cancer-immunity cycle. Here, we synthesize how ionic compe...
Sha Qin, Min-Min Xiang, Tania Tao et al.· Trends in Cell Biology· 0 citations
The efficacy of immune checkpoint blockade is limited in hepatocellular carcinoma (HCC) due to tumor-intrinsic mechanisms. Here we identify the deubiquitinase MINDY1 as a central regulator of metabolic-immune crosstalk that drives immunotherapy resistance in HCC. MINDY1 is significantly upregulated in immunotherapy non...
Ke-Jing Zhang, Kui Chen, Xing-Yu Mi et al.· Metabolism: Clinical and Exp...· 0 citations
This review comprehensively elucidates the pathophysiological mechanisms and translational potential of immune checkpoint regulation in obesity, diabetes, and thyroid disease while proposing novel directions for clinical intervention.
Min-Min Xiang, Shuang Liu, De-Sheng Xiao et al.· Signal Transduction and Targ...· 1 citation
It is shown that AP4M1 is markedly upregulated in HCC, correlates with unfavorable prognosis, and is functionally involved in driving HCC progression, providing a critical theoretical basis for AP4M1-targeted therapeutic strategies in HCC.
Yuan-Hao Peng, K. Kang, Xuanxuan Li et al.· Cancer Letters· 0 citations
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