De-Ling Wu

Paeonia lactiflora pall. Polysaccharide attenuates inflammation and improves intestinal barrier function in ulcerative colitis mice by modulating intestinal flora and inhibiting S100A8/A9/NF-κB signaling.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with substantial clinical burden and limited treatment options. PLPN-2, an α-glucan extracted from P. lactiflora, has shown anti-inflammatory activity in cellular and animal models, but its therapeutic mechanisms in UC remain unclear. Here, mice were...