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Author

De-Kun Hu

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Sep 2026

Discovery of A Safe and Effective Hemipteran Insecticide: α6 nAChR-Targeting Non-Mesoionic Scaffold

Triflumezopyrim, a mesoionic insecticide targeting nAChRs, effectively controls resistant hemipteran pests like planthoppers but raises concerns over non-target toxicity, especially to honeybees. In this study, we identified compound Q1, a pyrido[2,3-d]pyrimidine-2,4-dione derivative, which exhibits slightly superior...

Qing Li, Luo-Man Zhang, Hui-Hui Wu et al. · 0 citations
Jul 2026

Novel Pyrazole-Quinoxaline Conjugates as Potent HPPD-Inhibiting Herbicides with Notable Crop Safety.

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a vital target for herbicide development. A series of pyrazole-quinoxaline conjugates were designed and synthesized via scaffold hopping and structural optimization. Bioassays revealed that B9 exhibited potent inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) w...

Li Liu, Mei Zhang, Lingling Wang et al. · 0 citations

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