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De-Kuang Hwang

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Review Open access Oct 2026

Biosimilars in diabetic macular edema: Promise, progress, and pitfalls

Diabetic macular edema (DME) is a common microvascular complication of diabetes and a major cause of vision impairment. Intravitreal vascular endothelial growth factor (VEGF) inhibitors remain the gold standard for its management. However, the high cost and limited accessibility of reference anti-VEGF agents have drive...

Vanaja Jain, V. Dave, Manoj P. Shettigar et al. · 0 citations
Aug 2026

Inhibition of CXCR4-Induced Angiogenesis to Block Choroidal Neovascularization and Restore Retinal Function in Age-Related Macular Degeneration by In Silico-Selected Small Molecules.

Computational and experimental data demonstrate that BPRCX807 disrupts CXCR4 receptor interactions and suppresses angiogenic factor expression via inhibition of the CXCR4/p-AKT signaling pathway, representing a promising therapeutic approach for wet-AMD.

Shih-Jie Chou, Chia-Hao Wang, Ping-Hsing Tsai et al. · 0 citations

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