ABSTRACT Osteoporosis, characterized by imbalanced bone homeostasis, is driven by excessive osteoclast‐mediated bone resorption, yet the epitranscriptomic regulation via m6A modification remains unclear. Here, we identify WTAP, a component of the m6A methyltransferase complex, as a critical negative regulator of osteoc...
Chen Shen, Xin Liu, Gao-Ran Ge et al.· Advancement of science· 0 citations
As the global population ages, the prevalence of age-related conditions such as osteoporosis continues to increase, leading to greater use of orthopedic implants. However, implant-associated infections can cause severe complications, including loss of implant function, limb sequelae, and increased mortality. Biofilm fo...
Han-Rong Xia, Xing-Zhou Wei, Chen-Yang Jin et al.· BME Horizon· 0 citations
Diabetic bone regeneration is severely hindered by hyperglycemia-induced inflammation and microangiopathy. In this case, conventional drug strategies show limited efficacy. Inspired by the natural polyphenol structure, this study engineered a dual-network self-assembled hydrogel with glucose responsiveness and stage-ad...
XiaoQian Lu, Qifeng Sheng, Qi-Han Wang et al.· Biomaterials· 0 citations
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