Author

Dechun Geng

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Open access Oct 2026

GPX4‐Mediated Inhibition of Ferroptosis by Sodium Selenite Ameliorates Bone Metabolic Disorders in Ovariectomized Mice

ABSTRACT Postmenopausal osteoporosis (PMOP) and its associated fracture complications have emerged as pressing public health challenges due to rapidly accelerating global population ageing. The functional decline of bone marrow mesenchymal stem cells (BMSCs) under elevated oxidative stress is a recognised pathogenic co...

Wei-Hua Luo, Hai-Bo Xu, Xin Liu et al. · Journal of Cellular and Mole... · 0 citations

Aug 2026

Protein phosphatase 2A regulates nucleus pulposus autophagy and aggravates degeneration via the AKT/mTOR pathway.

It is proposed that PP2Ac induces autophagy in NP cells by activating the AKT/mTOR pathway, thereby facilitating NP degeneration.

Yi-Jie Liu, Yu-Jie Wang, Hong Zhou et al. · International Journal of Bio... · 0 citations

Jul 2026

The USP5-MATN3 axis in nucleus pulposus cell senescence: A Deubiquitination mechanism protecting against intervertebral disc degeneration.

This study clarifies the molecular mechanism by which the USP5/MATN3 axis regulates cellular senescence and affects IVDD progression, opening up new potential targets for the intervention strategy of IVDD.

Chunyang Fan, Jie-yun Xia, Yao Zhang et al. · Cellular Signalling · 0 citations