Open access
Sep 2026
Heritability and rare variant contributions to Alzheimer disease in the Midwestern Amish
Heritability estimates suggested that common variants explain much of genetic risk among APOE-{varepsilon}4 carriers, while unexplained heritability remains in non-carriers in the Amish, and GWAS confirmed APOE-{varepsilon}4 as the strongest genetic determinant of AD in the Amish.
Yi-Ning Liu, Yeunjoo E. Song, Wei-Huan Wang et al.
· medRxiv · 0 citations