Open access
Aug 2026
Molecular basis for the regulation of the SUMOylation activity of the Smc5/6 complex by Esc2
Post-translational modification by SUMO regulates a wide array of cellular processes. Despite the large number of SUMOylated substrates, only a limited set of SUMO E3 ligases have been identified, raising important questions about how substrate specificity is achieved. In budding yeast, the nuclear protein Esc2 functio...
Helena Borràs-Gas, Roger Solé-Soler, Rodolpho Do Aido-Machado et al.
· Communications Biology · 0 citations