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Author

David Ramírez

2 papers indexed here

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Sep 2026

The Sigma-1 Receptor as a Novel Target in the Neuroprotective Effects of Cannabidiol and Cannabigerol Against Mitochondrial Damage in Cultured Cerebellar Granule Neurons.

Cannabidiol (CBD) and cannabigerol (CBG) are nonpsychotomimetic phytocannabinoids with neuroprotective properties. We have previously reported that CBD and CBG, but not their acidic forms, protect cerebellar granule neurons from rotenone-induced toxicity. These effects were independent of canonical (i.e., cannabinoid 1...

Victoria Oviedo-Pino, Mariana Pazos, Giselle Prunell et al. · 0 citations
Open access Sep 2026

Design, Synthesis, and Cytotoxic Evaluation of N-Phenyl-3-(Thiophen-2-Yl)acrylamide Derivatives

A series of N-phenyl-3-(thiophen-2-yl)acrylamide derivatives were designed and synthesized to investigate the influence of electronic and steric modifications on cytotoxic activity. Although related thiophene-containing acrylamides have been reported, the specific compounds studied in this study have not been previousl...

Pablo S. Cavagnero, Felipe A. Zúñiga, Yaritza Ormazábal et al. · 0 citations

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