David Malkin

A microbiota-dependent gut bile acid axis links germline mutant p53 to distal tumour growth

Cancer Predisposition Syndromes in Children: Who, When, and How to Screen?

Childhood cancer predisposition syndromes (CPSs) are individually rare but collectively account for approximately 15%-20% of pediatric cancers. Advances in genomic testing have identified more than 100 cancer susceptibility genes, enabling earlier recognition of at-risk children and prompting implementation of structur...

Abstract C010: Updates from the Childhood Cancer Predisposition Study: A report from the Consortium for Childhood Cancer Predisposition

Genetic predisposition contributes to a much higher proportion of cancer in children than previously appreciated. This creates a unique opportunity to develop improved methods to identify children at increased risk for cancer, enable early detection or prevention of tumors, and improve cure rates with decreased m...

Childhood cancer predisposition study: a prospective registry and biorepository protocol

Introduction Cancer is the most common cause of disease-related mortality in children, highlighting the urgent need for improved care in this population. It is estimated that >15% of children diagnosed with cancer harbour a germline pathogenic variant in a cancer predisposition gene which confers an increased risk to d...