Open access
Sep 2026
Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration.
Alzheimer's disease and primary tauopathies are marked by changes in adaptive immunity, with increased brain CD8+ T cells correlating with tau pathology severity. However, how peripheral T cells get primed to enter the brain and contribute to tau-mediated neurodegeneration remains unclear. In different disease conditio...
Hao Hu, P. Lin, Carisa Zeng et al.
· Nature Neuroscience · 0 citations