Jul 2026
Property guidance for protein sequence generative models with ProteinGuide.
ProteinGuide is applied jointly with wet-lab data generation to increase the editing activity of an adenine base editor in vivo, resulting in a base editor with higher editing efficiency than was previously achieved using seven rounds of directed evolution.
Junhao Xiong, Ishan Gaur, Maria Lukarska et al.
· Nature Biotechnology · 1 citation