Antioxidant Upregulation Contributes to Improvements in Diaphragm Function Following Cervical Spinal Cord Injury and Hyperbaric Oxygen Therapy
Prevention of the HBO-induced upregulation of SOD1, SOD2 and GPX1 antioxidants reduces diaphragm-specific force production compared to the control, injured HBO-treated rats, providing evidence that the HBO-induced increase in SOD1, SOD2 and GPX1 antioxidant expression contributes, at least in part, to the therapeutic effect of HBO to preserve diaphragm function following cervical spinal cord injury.