Author

David A. Knowles

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Oct 2026

Mapping transcriptional responses to cellular perturbations with RNA fingerprinting.

Single-cell perturbation dictionaries measure how cells respond to genetic and chemical perturbations, creating the opportunity to assign causal interpretations to observational data. We introduce RNA fingerprinting, a statistical framework that maps transcriptional responses from new experiments onto reference perturb...

Isabella N. Grabski, Junsuk Lee, John D. Blair et al. · Cell · 0 citations

Open access Oct 2026

LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discovery.

SUMMARY Most human genes produce multiple RNA isoforms, yet it remains unclear which isoforms are translated into stable, functional proteins. Long-read RNA sequencing resolves full-length transcript structures and, when paired with mass spectrometry, can provide empirical evidence of isoform translation. Despite this...

Megan D. Schertzer, Julia T. Lewandowski, Emily F. Watts et al. · Bioinformatics · 0 citations