Darshan H. Divetia

Conventional and microwave-assisted synthesis of pyridine-linked 1,3,4-oxadiazole derivatives as promising antimicrobial agents: Structure-activity relationship and computational investigations using molecular docking, molecular dynamics simulation, MM-GBSA and DFT.

A novel series of pyridine-linked 2,2,5-trisubstituted 1,3,4-oxadiazole derivatives 4(a-o) was synthesized through conventional and microwave-assisted approaches using N-acylhydrazone intermediates derived from isoniazid and substituted acetophenones. Microwave irradiation significantly reduced reaction time while affo...