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Author

Daphne van den Berg

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Open access Sep 2026

PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism

Abstract Aims Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease in which most patients carry (likely) pathogenic variants in desmosomal genes, most commonly in plakophilin-2 (PKP2). While the genetic causes are well described, the molecular mechanisms driving disease progression—particularly in respon...

Su-Ji Han, Daphne van den Berg, H. de Ruiter et al. · 0 citations

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