Aug 2026
RUNX1-driven endothelial-to-mesenchymal transition contributes to remodelling in LMNA cardiomyopathy.
David Wu, D. Tripathi, Amit Manhas et al.
· European Heart Journal · 1 citation
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Open access
Aug 2026
Sirt1 inhibits the recruitment of RNA polymerase II to metabolic gene promoter during pressure overload through competition with the preinitiation complex on Sub1.
Sirt1 impairs metabolic gene transcription during PO by competitively inhibiting Sub1-mediated recruitment of GTFs and PIC formation, which contributes to the metabolic disturbance and may represent a maladaptive component of the heart failure phenotype.
Shin-ichi Oka, Youssef Mourad, Samta Veera et al.
· Cardiovascular Research · 0 citations