Sep 2026
Abstract PR007: Overcoming drug resistance in Sonic hedgehog-driven medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children, and the Group 2 (Sonic Hedgehog; SHH) subtype is driven by aberrant activation of the SHH signaling pathway. Several FDA-approved therapies target oncogenic SHH signaling by inhibiting SMOOTHENED (SMO), the primary membrane-associated regulato...
Rodney A. Stewart, Mattie Casey, Annabel Lee et al.
· Cancer Research · 0 citations