Open access
Sep 2026
Structural biology of the TRPM4 channel: architecture, modulation, and therapeutic opportunities
TRPM4 is a Ca 2+ -activated, monovalent-selective cation channel that conducts Na + and K + while remaining essentially impermeable to Ca 2+ . By translating cytosolic Ca 2+ elevations into membrane depolarization rather than additional Ca 2+ influx, TRPM4 operates as an electrical signal converter that t...
I. Araya-Durán, Marena Rein, Daniella Delgado et al.
· Frontiers in Pharmacology · 0 citations