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Daniel Rivkin

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Open access Jul 2026

N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases

Dynamic allostery is established as the mechanism of N-terminal activation in this subclass of serine proteases in a pathogenic methicillin-resistant S. aureus strain and mutational perturbation of this dynamic network modulates substrate engagement and catalytic activity in a manner consistent with dynamic control of binding competence.

Eunjeong Lee, J. Redzic, Samrat Sarkar et al. · 0 citations

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